Dr. Macdonald’s Scientific Activity
Recent Presentations by Dr. Macdonald
1. Invited Speaker, Presentation at Society for Brain Mapping and Therapeutics, ”Sustained Release Intracranial Drug Delivery for Traumatic Brain Injury,” June 2, 2012, Toronto, ON, Canada
2. Invited Speaker, Debate at Princeton Conference XXVIII, “Does Prevention of Vasospasm in SAH Improve Clinical Outcome: Yes,” May 18, 2012, Cincinnati, Ohio
3. Invited Speaker, Department of Defense, ”Intraventricular Administration of NimoVent (Site-specific, Sustained Release Nimodipine) to Prevent Secondary Brain Damage Following Traumatic Brain Injury,” May 11, 2012, Fort Detrick, Maryland
4. Invited Speaker, Jeremy Jeanes Neurocritical Care Conference, ”Vasospasm and SAH: Current Understanding, Pathophysiology and Treatment Options,” May 3-5, 2012, Banff, AB, Canada
5. Invited Speaker, Breakfast seminar at the 80th Annual Meeting of the American Association of Neurological Surgeons, “Diagnosis of Delayed Cerebral Ischemia,” April 14-18, 2012, Miami, Florida
6. Invited Speaker, Chicago Review Course in Neurosurgery, “Pathophysiology of Subarachnoid Hemorrhage and Vasospasm,” February 3, 2012, Chicago, IL
7. Invited Speaker, “Subarachnoid Hemorrhage Management”, 8th Annual Krembil Neuroscience Symposium, October 27, 2011, Toronto, ON, Canada
8. Moderator, Congress of Neurological Surgeons, “Multidisciplinary Management of Subarachnoid Hemorrhage and Vasospasm; Learning Objectives: Upon completion, participants will be able to compare the current surgical, interventional and medical management of subarachnoid hemorrhage and vasospasm secondary to ruptured intracranial aneurysms and vascular malformations,” October 2-5th, 2011, Washington, DC
9. Presenter, Congress of Neurological Surgeons, “Effect of Clazosentan on Clinical Outcome After Aneurysmal Subarachnoid Hemorrhage and Surgical Clipping: Results of the CONSCIOUS-2 Study,” October 2-5th, 2011, Washington, DC
10. Invited Attendee, “CONSCIOUS Expert meeting”, Actelion Steering Committee Meeting, September 9, 2011, Paris, France
11. Moderator, “Neurooncology, General Neuroradiology, Imaging digital posters”, 46th Annual Congress of the Canadian Neurological Sciences Federation, June 15-17, 2011, Vancouver, B.C., Canada
12. Invited Speaker, “Site-Specific, Sustained Release Drug Delivery for Prevention of Complications of Traumatic Brain Injury”, Traumatic Brain Injury Conference, March 7, 2011, Washington, DC
13. Invited Speaker, “Vasospasm Basic Research: What Have We Learnt in the Past Decade and Why Is Magnesium of Interest?”, International Stroke Conference, February 9-11, 2011, Los Angeles, CA
14. Invited Speaker, “Pathophysiology of Subarachnoid Hemorrhage and Vasospasm”, Chicago Review Course in Neurosurgery, February 4, 2011, Chicago, IL
15. Invited Speaker, “Subarachnoid hemorrage and vasospasm”, Chicago review course in neurosurgery – February 4, 2011 in Chicago, IL
16. Invited Speaker, “New Therapies for Subarachnoid Hemorrhage”, 40th Critical Care Congress, Society of Critical Care Medicine, San Diego, California, January 15-19, 2011
17. Presenter, 72nd Annual Meeting of the American Academy of Neurological Surgery – November 3-6, 2010 in Pebble Beach, CA
18. Poster, CNS Annual Meeting – October 16-21, 2010
19. Moderator, Subarachnoid hemorrhage and vasospasm seminar, Congress of Neurological Surgeons 2010 CNS Annual Meeting – October 16-21, 2010 in San Francisco, CA
Recent Publications by Dr. Macdonald
1: Hasan D, Hashimoto T, Kung D, Macdonald RL, Winn HR, Heistad D. Upregulation of Cyclooxygenase-2 (COX-2) and Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) in Wall of Ruptured Human Cerebral Aneurysms: Preliminary Results. Stroke. 2012 May 15. [Epub ahead of print] PubMed PMID: 22588264.
2: Macdonald RL. Editorial: Outcome after aneurysmal subarachnoid hemorrhage. J Neurosurg. 2012 Apr 27. [Epub ahead of print] PubMed PMID: 22540401.
3: Zoerle T, Ilodigwe DC, Wan H, Lakovic K, Sabri M, Ai J, Macdonald RL. Pharmacologic reduction of angiographic vasospasm in experimental subarachnoid hemorrhage: systematic review and meta-analysis. J Cereb Blood Flow Metab. 2012 Apr 25. doi: 10.1038/jcbfm.2012.57. [Epub ahead of print] PubMed PMID: 22534672.
4: Cook DJ, Kan S, Ai J, Kasuya H, Macdonald RL. Cisternal sustained release dihydropyridines for subarachnoid hemorrhage. Curr Neurovasc Res. 2012 May 1;9(2):139-48. PubMed PMID: 22475399.
5: Macdonald RL. Editorial: Mirror aneurysms. J Neurosurg. 2012 Jun;116(6):1235-7. Epub 2012 Mar 9. PubMed PMID: 22404674.
6: Macdonald RL, Higashida RT, Keller E, Mayer SA, Molyneux A, Raabe A, Vajkoczy P, Wanke I, Bach D, Frey A, Nowbakht P, Roux S, Kassell N. Randomized trial of calzosentan in patients with aneurysmal subarachnoid hemorrhage undergoing endovascular coiling. Stroke. 2012 Jun;43(6):1463-9. Epub 2012 Mar 8. PubMed PMID: 22403047.
7: Fine B, Singh N, Aviv R, Macdonald RL. Decisions: does a patient with a thunderclap headache need a lumbar puncture? CMAJ. 2012 Mar 20;184(5):555-6. Epub 2012 Mar 5. PubMed PMID: 22392938.
8: Macdonald RL, Hunsche E, Schüler R, Wlodarczyk J, Mayer SA. Quality of life and healthcare resource use associated with angiographic vasospasm after aneurysmal subarachnoid hemorrhage. Stroke. 2012 Apr;43(4):1082-8. Epub 2012 Feb 9. PubMed PMID: 22328549.
9: Sheldon S, Macdonald RL, Schweizer TA. Free recall memory performance after aneurysmal subarachnoid hemorrhage. J Int Neuropsychol Soc. 2012 Mar;18(2):334-42. Epub 2012 Feb 13. PubMed PMID: 22325677.
10: Schweizer TA, Al-Khindi T, Macdonald RL. Mini-Mental State Examination versus Montreal Cognitive Assessment: rapid assessment tools for cognitive and functional outcome after aneurysmal subarachnoid hemorrhage. J Neurol Sci. 2012 May 15;316(1-2):137-40. Epub 2012 Jan 26. PubMed PMID: 22280947.
11: Suarez JI, Martin RH, Calvillo E, Dillon C, Bershad EM, Macdonald RL, Wong J, Harbaugh R; ALISAH Investigators. The Albumin in Subarachnoid Hemorrhage (ALISAH) multicenter pilot clinical trial: safety and neurological outcomes. Stroke. 2012 Mar;43(3):683-90. Epub 2012 Jan 19. PubMed PMID: 22267829.
12: Ibrahim GM, Macdonald RL. Letter to the Editor regarding: Method of Aneurysm Treatment Does Not Affect Clot Clearance After Aneurysmal Subarachnoid Hemorrhage. Neurosurgery. 2012 Jan 18. [Epub ahead of print] PubMed PMID: 22262144.
13: Macdonald RL. Shunts and aneurysms. World Neurosurg. 2011 Dec;76(6):520-1. PubMed PMID: 22251495.
14: Macdonald RL. Editorial: on the persisting difficulty of making decisions, especially about the future. J Neurosurg. 2012 Apr;116(4):866-9; discussion 869-70. Epub 2012 Jan 13. PubMed PMID:22242673.
15. Strong AJ, Macdonald RL. Cortical spreading ischemia in the absence of proximal vasospasm after aneurysmal subarachnoid hemorrhage: evidence for a dual mechanism of delayed cerebral ischemia. J Cereb Blood Flow Metab. 2011 Dec 7. doi: 10.1038/jcbfm.2011.170. [Epub ahead of print] PubMed PMID: 22146191.
16: Macdonald RL. Dissecting the Complexities of Aneurysm Hemodynamics. World Neurosurg. 2011 Nov 1. [Epub ahead of print] PubMed PMID: 22120234.
17: Macdonald RL. Nimodipine-Oral or Intravenous? No-Subarachnoid. World Neurosurg. 2011 Nov 1. [Epub ahead of print] PubMed PMID: 22120216.
18: Macdonald RL. Editorial. J Neurosurg. 2011 Nov 18. [Epub ahead of print] PubMed PMID: 22098197.
19: Ibrahim GM, Weidauer S, Vatter H, Raabe A, Macdonald RL. Attributing Hypodensities on CT to Angiographic Vasospasm Is Not Sensitive and Unreliable. Stroke. 2012 Jan;43(1):109-12. Epub 2011 Oct 13. PubMed PMID: 21998061.
20: Crowley RW, Macdonald RL. Is vasospasm actually bad for you? World Neurosurg. 2011 Jul-Aug;76(1-2):6. PubMed PMID: 21839927.
21: Vergouwen MD, Etminan N, Ilodigwe D, Macdonald RL. Lower incidence of cerebral infarction correlates with improved functional outcome after aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2011 Jul;31(7):1545-53. doi: 10.1038/jcbfm.2011.56. Epub 2011 Apr 20. Review. PubMed PMID: 21505477; PubMed Central PMCID: PMC3137476.
22: Tang J, Ai J, Macdonald RL. Developing a model of chronic subdural hematoma. Acta Neurochir Suppl. 2011;111:25-9. Review. PubMed PMID: 21725727.
23: Ibrahim GM, Weidauer S, Macdonald RL. Interobserver variability in the interpretation of computed tomography following aneurysmal subarachnoid hemorrhage. J Neurosurg. 2011 Dec;115(6):1191-6. Epub 2011 Aug 5. PubMed PMID: 21819195.
24: Ibrahim GM, Vachhrajani S, Ilodigwe D, Stat M, Kassell NF, Mayer SA, Ruefenacht D, Schmiedek P, Weidauer S, Pasqualin A, Macdonald RL. Method of Aneurysm Treatment Does Not Affect Clot Clearance After Aneurysmal Subarachnoid Hemorrhage. Neurosurgery. 2011 Jul 20. [Epub ahead of print] PubMed PMID: 21788917.
25: Macdonald RL, Higashida RT, Keller E, Mayer SA, Molyneux A, Raabe A, Vajkoczy P, Wanke I, Bach D, Frey A, Marr A, Roux S, Kassell N. Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2). Lancet Neurol. 2011 Jul;10(7):618-25. Epub 2011 Jun 2. PubMed PMID: 21640651.
26: Takahashi M, Zhang ZD, Macdonald RL. Sphenopalatine ganglion stimulation for vasospasm after experimental subarachnoid hemorrhage. J Neurosurg. 2011 Apr;114(4):1104-9. Epub 2010 Jul 2. PubMed PMID: 20597600.
27: Vergouwen MD, Ilodigwe D, Macdonald RL. Cerebral infarction after subarachnoid hemorrhage contributes to poor outcome by vasospasm-dependent and -independent effects. Stroke. 2011 Apr;42(4):924-9. Epub 2011 Feb 10. PubMed PMID: 21311062.
28: Etminan N, Vergouwen MD, Ilodigwe D, Macdonald RL. Effect of pharmaceutical treatment on vasospasm, delayed cerebral ischemia, and clinical outcome in patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. J Cereb Blood Flow Metab. 2011 Feb 2. [Epub ahead of print] PubMed PMID: 21285966.
29: Sabri M, Ai J, Knight B, Tariq A, Jeon H, Shang X, Marsden PA, Loch Macdonald R. Uncoupling of endothelial nitric oxide synthase after experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2011 Jan;31(1):190-9. Epub 2010 Jun 2. PubMed PMID: 20517322; PubMed Central PMCID: PMC3049483.
30: DeMarchi R, Abu-Abed S, Munoz D, Loch Macdonald R. Malignant ganglioglioma: case report and review of literature. J Neurooncol. 2011 Jan;101(2):311-8. Epub 2010 Jun 4. Review. PubMed PMID: 20524041.
31: Kramer AH, Diringer MN, Suarez JI, Naidech AM, Macdonald LR, Le Roux PD. Red blood cell transfusion in patients with subarachnoid hemorrhage: a multidisciplinary North American survey. Crit Care. 2011;15(1):R30. Epub 2011 Jan 18. PubMed PMID: 21244675; PubMed Central PMCID: PMC3222066.
32: Macdonald RL, Higashida RT, Keller E, Mayer SA, Molyneux A, Raabe A, Vajkoczy P, Wanke I, Frey A, Marr A, Roux S, Kassell NF. Preventing vasospasm improves outcome after aneurysmal subarachnoid hemorrhage: rationale and design of CONSCIOUS-2 and CONSCIOUS-3 trials. Neurocrit Care. 2010 Dec;13(3):416-24. PubMed PMID: 20838933.
33: Dumont AS, Crowley RW, Monteith SJ, Ilodigwe D, Kassell NF, Mayer S, Ruefenacht D, Weidauer S, Pasqualin A, Macdonald RL. Endovascular treatment or neurosurgical clipping of ruptured intracranial aneurysms: effect on angiographic vasospasm, delayed ischemic neurological deficit, cerebral infarction, and clinical outcome. Stroke. 2010 Nov;41(11):2519-24. Epub 2010 Sep 2. PubMed PMID: 20813994.
34: Tam AK, Ilodigwe D, Mocco J, Mayer S, Kassell N, Ruefenacht D, Schmiedek P, Weidauer S, Pasqualin A, Macdonald RL. Impact of systemic inflammatory response syndrome on vasospasm, cerebral infarction, and outcome after subarachnoid hemorrhage: exploratory analysis of CONSCIOUS-1 database. Neurocrit Care. 2010 Oct;13(2):182-9. PubMed PMID: 20593247.
35: Vergouwen MD, Vermeulen M, van Gijn J, Rinkel GJ, Wijdicks EF, Muizelaar JP, Mendelow AD, Juvela S, Yonas H, Terbrugge KG, Macdonald RL, Diringer MN, Broderick JP, Dreier JP, Roos YB. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke. 2010 Oct;41(10):2391-5. Epub 2010 Aug 26. PubMed PMID: 20798370.
36: Morgenstern LB, Hemphill JC 3rd, Anderson C, Becker K, Broderick JP, Connolly ES Jr, Greenberg SM, Huang JN, MacDonald RL, Messé SR, Mitchell PH, Selim M, Tamargo RJ; American Heart Association Stroke Council and Council on Cardiovascular Nursing. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2010 Sep;41(9):2108-29. Epub 2010 Jul 22. PubMed PMID: 20651276.
37: Schweizer TA, Macdonald RL. Brain hemorrhage: assessing outcome after subarachnoid hemorrhage. Nat Rev Neurol. 2010 Aug;6(8):427-8. PubMed PMID: 20689567.
38: Ferguson SD, Rosen DS, Bardo D, Macdonald RL. Arterial diameters on catheter and computed tomographic angiography. World Neurosurg. 2010 Mar;73(3):165-73; discussion e25. Epub 2009 Jul 15. PubMed PMID: 20860954.
